News Review
Scientists Finding Out What Losing Sleep Does to a Body
By Rob Stein, Washington Post Staff Writer
Sunday, October 9, 2005
Scientific References
Positive affect, psychological well-being, and good sleep.
Steptoe A, O'Donnell K, Marmot M, Wardle J.
J Psychosom Res. 2008 Apr;64(4):409-15.
Positive well-being and sleep. Roberts RE, J Psychosom Res. 2008 Apr;64(4):417-8.
Sleep, Disease Risks and Mortality
Sleep and society: an epidemiological perspective.
Bixler E. Sleep Med. 2009 Sep;10 Suppl 1:S3-6.
The public health and safety consequences of sleep disorders, Sigurdson K, Ayas. Canadian J Physiol Pharmacol. 85:179-183.
Sleep and mortality: a population-based 22-year follow-up study, Hublin C, Partinen M, Koskenvuo M, Kaprio J. Sleep. 2007 Oct 1;30(10):1245-53.
Sleep duration and all-cause mortality: a systematic review and meta-analysis of prospective studies.
Cappuccio FP, D'Elia L, Strazzullo P, Miller MA. Sleep. 2010 May 1;33(5):585-92.
Sleep duration and mortality: a systematic review and meta-analysis.
Gallicchio L, Kalesan B. J Sleep Res. 2009 Jun;18(2):148-58.
Mortality associated with sleep duration and insomnia.
Kripke DF, Garfinkel L, Wingard DL, Klauber MR, Marler MR.
Arch Gen Psychiatry. 2002 Feb;59(2):131-6.
A prospective study of sleep duration and mortality risk in women, Patel SR, Ayas NT, Malhotra MR, White DP, Schernhammer ES, Speizer FE, Stampfer MJ, Hu FB. Sleep. 2004 May 1;27(3):440-4.
Sleep and Alzheimer’s Disease
Amyloid-β dynamics are regulated by orexin and the sleep-wake cycle.
Jae-Eun Kang, Miranda M. Lim, Randall J. Bateman, James J. Lee, Liam P. Smyth, John R. Cirrito, Nobuhiro Fujiki, Seiji Nishino, David M. Holtzman
Science 326, 1005–1007 (2009).
- Abstract: Amyloid-β (Aβ) accumulation in the brain extracellular space is a hallmark of Alzheimer’s disease. The factors regulating this process are only partly understood. Aβ aggregation is a concentration-dependent process that is likely responsive to changes in brain interstitial fluid (ISF) levels of Aβ. Using in vivo microdialysis in mice, we found that the amount of ISF Aβ correlated with wakefulness. The amount of ISF Aβ also significantly increased during acute sleep deprivation and during orexin infusion, but decreased with infusion of a dual orexin receptor antagonist. Chronic sleep restriction significantly increased, and a dual orexin receptor antagonist decreased, Aβ plaque formation in amyloid precursor protein transgenic mice. Thus, the sleep-wake cycle and orexin may play a role in the pathogenesis of Alzheimer’s disease.
Sleep and Cardiovascular Diseases
Sleep duration and risk of ischemic stroke in postmenopausal women.
Chen JC, Brunner RL, Ren H, Wassertheil-Smoller S, Larson JC, Levine DW, Allison M, Naughton MJ, Stefanick ML., Stroke. 2008 Dec;39(12):3185-92. Epub 2008 Jul 17.
Habitual sleep duration and insomnia and the risk of cardiovascular events and all-cause death: report from a community-based cohort.
Chien KL, Chen PC, Hsu HC, Su TC, Sung FC, Chen MF, Lee YT.
Sleep. 2010 Feb 1;33(2):177-84.
Inflammatory aspects of sleep apnea and their cardiovascular consequences, Kasasbeh E, Chi DS, Krishnaswamy G. South Med J 2006;99:58–67.
Association of sleep duration with mortality from cardiovascular disease and other causes for Japanese men and women: the JACC study.
Ikehara S, Iso H, Date C, Kikuchi S, Watanabe Y, Wada Y, Inaba Y, Tamakoshi A; JACC Study Group. Sleep. 2009 Mar 1;32(3):295-301.
Habitual sleep patterns and risk for stroke and coronary heart disease: a 10-year follow-up from NHANES I., Qureshi AI, Giles WH, Croft JB, Bliwise DL. Neurology. 1997 Apr;48(4):904-11.
Sleep and Other Diseases
Role of sleep duration and quality in the risk and severity of type 2 diabetes mellitus. Knutson KL, Ryden AM, Mander VA, Van Cauter E. Arch Intern Med 2006;166:1768–1774.
Symptoms of depression in individuals with obstructive sleep apnea may be amenable to treatment with continuous positive airway pressure. Schwartz DJ, Kohler WC, Karatinos G. Chest 2005;128:1304–1306.
The link between short sleep duration and obesity: We should recommend more sleep to prevent obesity, Taheri S. Arch Dis Child 2006;91:881–884.
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